tfa transferrin-a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tfaprovided by ZNC
Official Full Name: transferrin-aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-35
See related: Ensembl:ENSDARG00000016771 AllianceGenome:ZFIN:ZDB-GENE-980526-35
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: trf; gavi; cb285; sb:cb285; id:ibd3238; id:ibd3525; wu:fb57g06; wu:fb62h02; wu:fb63h10; wu:fb64h10; zgc:112154
Summary: Predicted to enable metal ion binding activity. Acts upstream of or within hemoglobin biosynthetic process; iron ion transport; and response to bacterium. Predicted to be located in extracellular region. Predicted to be active in endosome; extracellular space; and plasma membrane. Is expressed in several structures, including ball; liver; ovary; renal system; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including atransferrinemia; carcinoma (multiple); glucose metabolism disease (multiple); iron deficiency anemia; and restless legs syndrome. Orthologous to several human genes including TF (transferrin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (16780634..16792177)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (17112044..17123587)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The zebrafish hypochromic anemia mutant, gavi, exhibits transferrin deficiency due to mutations in transferrin-a.Transferrin-a plays a critical role both in iron transport & in regulating hepcidin expression in zebrafish embryos.
Title: Transferrin-a modulates hepcidin expression in zebrafish embryos.
transferrin mRNAs in zebrafish were first expressed at approximately 7 hours postfertilization (hpf) in the yolk syncytial layer and later in the liver rudiment (48 hpf) and in the esophagus transiently (72-96 hpf)
Title: Expression analyses of zebrafish transferrin, ifabp, and elastaseB mRNAs as differentiation markers for the three major endodermal organs: liver, intestine, and exocrine pancreas.

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General gene information

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Markers

fa29h04.s1 (e-PCR)
- UniSTS:202508

fc35g08.x1 (e-PCR)
- UniSTS:193643

fb63h10 (e-PCR)
- UniSTS:189044

tfa (e-PCR), detects polymorphism
- UniSTS:205489

TFA (e-PCR)
- UniSTS:205306

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hemoglobin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in iron ion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within iron ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within iron ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in recycling endosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transferrin-a

Names: transferrin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291499.1 → NP_001278428.1 transferrin-a precursor

Status: VALIDATED

Source sequence(s)

BC064001, CU462977, EH570320

UniProtKB/TrEMBL

A0A8M1P0N7, B8JL43

Related

ENSDARP00000100241.3, ENSDART00000108611.6

Conserved Domains (2) summary

smart00094
Location:341 → 653

TR_FER; Transferrin

cl21456
Location:336 → 648

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

16780634..16792177

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001015057.1: Suppressed sequence

Description

NM_001015057.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.